Preparation of azaindolines and benzoyl substituted azaindolines: precursors of triazabenzo[cd]azulen-9-one PDE4 inhibitorsBADLAND, Matthew; DEVILLERS, Ingrid; WRIGGLESWORTH, Roger et al.Tetrahedron letters. 2011, Vol 52, Num 41, issn 0040-4039, 5202, 5292-5296 [6 p.]Article

Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitorsPACKARD, Garrick K; PAPA, Patrick; MCCARRICK, Margaret A et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 1, pp 747-752, issn 0960-894X, 6 p.Article

C-C bond formation at C-2 of a quinoline ring: Synthesis of 2-(1H-indol-3-yl) quinoline-3-carbonitrile derivatives as a new class of PDE4 inhibitorsSHIVA KUMAR, K; KIRAN KUMAR, S; PAL, Manojit et al.Bioorganic & medicinal chemistry. 2012, Vol 20, Num 7, pp 2199-2207, issn 0968-0896, 9 p.Article

Design and synthesis of 4-alkynyl pyrazoles as inhibitors of PDE4: A practical access via Pd/C-Cu catalysisRAO GORJA, Dhilli; SHIVA KUMAR, K; KANDALE, Ajit et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 7, pp 2480-2487, issn 0960-894X, 8 p.Article

Inhibition of cyclooxygenase-2 prevents adverse effects induced by phosphodiesterase type 4 inhibitors in ratsPETER, D; GÖGGEL, R; COLBATZKY, F et al.British journal of pharmacology. 2011, Vol 162, Num 2, pp 415-427, issn 0007-1188, 13 p.Article

THE NOVEL DISTRIBUTION OF PHOSPHODIESTERASE-4 SUBTYPES WITHIN THE RAT RETINAWHITAKER, C. M; COOPER, N. G. F.Neuroscience. 2009, Vol 163, Num 4, pp 1277-1291, issn 0306-4522, 15 p.Article

Phosphodiesterase genes and antidepressant treatment response : A reviewESPOSITO, Karin; REIERSON, Gillian W; HUAI RONG LUO et al.Annals of medicine (Helsinki). 2009, Vol 41, Num 3, pp 177-185, issn 0785-3890, 9 p.Article

PDE4 inhibitors : current status. CommentaryGIEMBYCZ, M. A; SPINA, D.British journal of pharmacology. 2008, Vol 155, Num 3, issn 0007-1188, 288-290, 308-315 [11 p.]Article

Suppression of detrusor overactivity in rats with bladder outlet obstruction by a type 4 phosphodiesterase inhibitorNISHIGUCHI, Jun; DONG DEUK KWON; KAIHO, Yasuhiro et al.BJU international (Papier). 2007, Vol 99, Num 3, pp 680-686, issn 1464-4096, 7 p.Article

Phosphodiesterase inhibitorsBOSWELL-SMITH, Victoria; SPINA, Domenico; PAGE, Clive P et al.British journal of pharmacology. 2006, Vol 147, issn 0007-1188, S252-S257, SUP1Article

Regulation of cAMP phosphodiesterase mRNAs expression in rat brain by acute and chronic fluoxetine treatment. An in situ hybridization studyMIRO, Xavier; PEREZ-TORRES, Silvia; ARTIGAS, Francesc et al.Neuropharmacology. 2002, Vol 43, Num 7, pp 1148-1157, issn 0028-3908, 10 p.Article

Montmorillonite K-10 mediated green synthesis of cyano pyridines: Their evaluation as potential inhibitors of PDE4RAM REDDY, T; RAJESHWAR REDDY, G; SRINIVASULA REDDY, L et al.European journal of medicinal chemistry. 2012, Vol 48, pp 265-274, issn 0223-5234, 10 p.Article

Etazolate improves performance in a foraging and homing task in aged ratsDROTT, Jason; DESIRE, L; DROUIN, D et al.European journal of pharmacology. 2010, Vol 634, Num 1-3, pp 95-100, issn 0014-2999, 6 p.Article

Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitorsSKOUMBOURDIS, Amanda P; LECLAIR, Christopher A; MICHNICK, Stephen W et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 13, pp 3686-3692, issn 0960-894X, 7 p.Article

Application of Drug Repositioning Strategy to TOFISOPAMBERNARD, P; DUFRESNE-FAVETTA, C; FAVETTA, P et al.Current medicinal chemistry. 2008, Vol 15, Num 30, pp 3196-3203, issn 0929-8673, 8 p.Article

L-454,560, a potent and selective PDE4 inhibitor with in uiuo efficacy in animal models of asthma and cognitionHUANG, Z; DIAS, R; GOETGHEBEUR, P et al.Biochemical pharmacology. 2007, Vol 73, Num 12, pp 1971-1981, issn 0006-2952, 11 p.Article

PI3Kγ is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytesKERFANT, Benoit-Gilles; DONGLING ZHAO; LORENZEN-SCHMIDT, Ilka et al.Circulation research. 2007, Vol 101, Num 4, pp 400-408, issn 0009-7330, 9 p.Article

Selective induction of cAMP phosphodiesterase PDE4B2 expression in experimental autoimmune encephalomyelitisREYES-IRISARRI, Elisabet; SANCHEZ, Antonio J; GARCIA-MERINO, Juan Antonio et al.Journal of neuropathology and experimental neurology. 2007, Vol 66, Num 10, pp 923-931, issn 0022-3069, 9 p.Article

Discovery of a substituted 8-arylquinoline series of PED4 inhibitors : Structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitorMACDONALD, Dwight; MASTRACCHIO, Anthony; CHUN LI et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 23, pp 5241-5246, issn 0960-894X, 6 p.Article

Blockade of LTC₄ synthesis caused by additive inhibition of glV-PLA₂ phosphorylation: Effect of salmeterol and PDE4 inhibition in human eosinophilsMELITON, Angelo Y; MUNOZ, Nilda M; JIE LIU et al.Journal of allergy and clinical immunology. 2003, Vol 112, Num 2, pp 404-410, issn 0091-6749, 7 p.Article

Bioactive triterpenoids from Vochysia pacifica interact with cyclic nucleotide phosphodiesterase isozyme PDE4WENIGER, Bernard; LOBSTEIN, Annelise; UM, Byung-Hun et al.PTR. Phytotherapy research. 2005, Vol 19, Num 1, pp 75-77, issn 0951-418X, 3 p.Article

Conformationally restricted novel pyrazole derivatives: Synthesis of 1,8-disubstituted 5,5-dimethyl-4,5-dihydro-1H-benzo[g]indazoles as a new class of PDE4 inhibitorsSHYAMSUNDER REDDY, T; SHIVA KUMAR, K; NAIDU, A et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 9, pp 3248-3255, issn 0960-894X, 8 p.Article

Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitorCHEN, Shang-Ke; PENG ZHAO; SHAO, Yong-Xian et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 9, pp 3261-3264, issn 0960-894X, 4 p.Article

β-Adrenergic receptor stimulation increases surface NKCC2 expression in rat thick ascending limbs in a process inhibited by phosphodiesterase 4HAQUE, Mohammed Z; CACERES, Paulo S; ORTIZ, Pablo A et al.American journal of physiology. Renal physiology. 2012, Vol 72, Num 5, issn 1931-857X, F1307-F1314Article

Thiophene inhibitors of PDE4: Crystal structures show a second binding mode at the catalytic domain of PDE4D2NANKERVIS, Jacob L; FEIL, Susanne C; MANALLACK, David T et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 23, pp 7089-7093, issn 0960-894X, 5 p.Article